Basic Information
VIS ID
TVIS10008926
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1838
Orient
+
Integrated sequence
GAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCT| |AATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACT
Host Sequence
Chromosome
chr4
Cytoband
q26
Reference genome
GRCh37/hg19
Start
117480767/116559611 (Hg38)
End
117480767/116559611 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/1902757; hsa-mir-1305/Downstream/8947648;
Nearest TSS
ENST00000502981/Upstream/44465; ENST00000420701/Downstream/525965;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/1959835, chr4-CpG: 21/Downstream/39664
Nearby gene
MIR1973(-259843) ; TRAM1L1(+523943) ;
Upstream sequence
ttcctggaaggtagtgcgcccctccccacatgccgggccccacatttatttctgaactttttgcaatgtccgctaaaatacaacggcaaatgtaagtgct
Downstream sequence
gagggatagcattaggagaaacatctattgtagatgacaggttgatgggtacagcaaaccactatgtcatgtgtatagctatgtaacaaacctgcacgtt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate