Basic Information
VIS ID
TVIS10008927
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1985
Orient
+
Integrated sequence
TTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACG| |AGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGC
Host Sequence
Chromosome
chr4
Cytoband
q28.3
Reference genome
GRCh37/hg19
Start
134827433/133906278 (Hg38)
End
134827433/133906278 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/8398971; hsa-mir-1305/Downstream/9437182;
Nearest TSS
ENST00000502981/Upstream/751385; ENST00000503009/Downstream/104412;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/753805, chr4-CpG: 21/Downstream/1037947
Nearby gene
PCDH10(-714701) ; PABPC4L(+290056) ;
Nearest cancer related gene
PCDH10(TSG, -714701) ;
Upstream sequence
gaacccaatggaatggaatggattgcaatggaatggaacggaattaactggagtggaatggaatgtaatggaatgcagtggaatggaatggaacggaatg
Downstream sequence
attcttggcttgttcactgttggtgtatagcagcgctattgatttctgtatattttgtaccctgaaactttactgaatttatttatcagttttaggagct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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