Basic Information
VIS ID
TVIS10008936
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1818
Orient
+
Integrated sequence
GTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATG| |CAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTT
Host Sequence
Chromosome
chr4
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
30266492/30264870 (Hg38)
End
30266492/30264870 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA4D
Nearest miRNA
hsa-mir-12113/Upstream/1445202; hsa-mir-1243/Downstream/6161496;
Nearest TSS
ENST00000502981/Upstream/1050472; ENST00000507864/Downstream/455545;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/3403254, chr4-CpG: 55/Downstream/13229
Nearby gene
MIR4275(-1445202) ; PCDH7(+455538) ;
Upstream sequence
gttcctacctaataaaggtgaagattacatgaaataaagtatgacgtgcagactaagcatctaatacataTTTTCAACATAATTGGCAAAAAGTGCAGGG
Downstream sequence
cgtggagtcaggagcaatttttgccagcaggggatggatgttacaaagtacattcataagggaggggaggatgtattgtcacaagggcggggaagaatgt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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