Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10008937
Fusion event
HBV-KCTD8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
X protein|precore/core protein|
Start
1821
Orient
+
Integrated sequence
TGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAA| |CTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATA
Host Sequence
Chromosome
chr4
Cytoband
p13
Reference genome
Start
End
44335339/44333322 (Hg38)
Orient
+
Location type
Intronic
Target gene
Nearest miRNA
hsa-mir-12113/Upstream/3831203; hsa-mir-1243/Downstream/3319347;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/1675789, chr4-CpG: 174/Downstream/114047
Upstream sequence
GTCATAAGTAAATTTCTGTTTCAGCAAGTGTTACTTACAAGGAGAAAAAAAGGCATCCCCAAGCTGGTATGAACTTTACTCTCAAAGGGCTTTGTTACTA
Downstream sequence
TTTAATAAGTCGCAAGCAAACCAAAAGAAGGCTTTTATAGGAAACATTCTTAATAAAAACCTGGGCTACTGTCTTAAGTAAAGATGTAAGTCAATACTTC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.