VISDB Viral Integration Site DataBase

VIS ID

TVIS10008938

Fusion event

HBV-FRYL integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|

Start

1342

Orient

+

Integrated sequence

GAACCTTTTCGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCCGCTTGTTTTGCTCGCAGCAGGTCTGGAGCAAACATTATCGGGACTGATAACTC| |TGTTGTCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCG

Chromosome

chr4

Cytoband

p11

Reference genome

Start

End

48602169/48600152 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-15b-5p ; hsa-mir-1261 ; hsa-mir-128-3p ; hsa-mir-216a-3p ; hsa-mir-224-5p ; hsa-mir-27a-3p ; hsa-mir-27b-3p ; hsa-mir-3171 ; hsa-mir-3681-3p ; hsa-mir-3681-5p ; hsa-mir-376b-5p ; hsa-mir-376c-5p ; hsa-mir-6849-5p

Nearest miRNA

hsa-mir-12113/Upstream/947409; hsa-mir-1243/Downstream/4112530;

Nearest TSS

Nearest CpG islands

None/Target, chr4-CpG: 46/Upstream/108580, chr4-CpG: 121/Downstream/179162

Upstream sequence

caaaataacgagttggctcccagtatctttgcaggttgatcaattttgttttgtaaaaatatatattattaagcgcttatggattttgaacacctaattt

Downstream sequence

TTAGTATCAAGAGATTAAATGGATCTCAAAATAGTTTAGGTAAGGCCTTTATCTTGGATCAATTTTCCCTATACATAAAATAAATAACTGTTACAACAGA