Basic Information
VIS ID
TVIS10008948
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1053
Orient
-
Integrated sequence
AAACTTCCTATTAACAGGCCTATTGATTGGAAAGTATGTCAACGAATTGTGGGTCTTTTGGGTTTTGCTGCCCCTTTTACACAATGTGGTTATCCTGCGT| |TGATGCCTTTGTATGCATGTATTCAATCTAAGCAGGCTTTCACTTTCTCGCCAACTTACAAGGCCTTTCTGTGTAAACAATACCTGAACCTTTACCCCGT
Host Sequence
Chromosome
chr4
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
93224118/92302967 (Hg38)
End
93224118/92302967 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA4E
Nearest miRNA
hsa-mir-12113/Upstream/5002384; hsa-mir-1243/Downstream/6694420;
Nearest TSS
ENST00000502981/Upstream/25892; ENST00000515744/Downstream/655;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/120165, chr4-CpG: 63/Downstream/2230
Nearby gene
CCSER1(-700748) ; GRID2(+1432) ;
Upstream sequence
GTATTTTTAATGTATTAATCCAATTAGTTTTTTCAAAAGTTGCACTTTGAGGCTATTTTTAAATCTACCATTATACACTACAGTGTGAATATATGAGCTT
Downstream sequence
GTCAATCATTATAAGAAAAGAAGTCACAATGATCAGGATTTTATCTTAAGGAATAAGCTTGCAGAAAATCCTTTCACTGGAGACTGAGAGGCTGTCATTC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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