Basic Information
VIS ID
TVIS10008949
Fusion event
HBV-LOC105379107 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2843
Orient
+
Integrated sequence
CACTATTTACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATC| |TACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATT
Host Sequence
Chromosome
chr5
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
103260004/103924303 (Hg38)
End
103260004/103924303 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5F
Target gene
LOC105379107
Nearest miRNA
hsa-mir-10397/Upstream/3107738; hsa-mir-103a-1/Downstream/6589526;
Nearest TSS
ENST00000502646/Upstream/361510; ENST00000514769/Downstream/155608;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/664454, chr5-CpG: 253/Downstream/3745126
Nearby gene
NUDT12(-361514) ; RAB9BP1(+1175171) ;
Upstream sequence
AGGCGCGTAGACGCGGCTGGGGACGAACCCGAGGACGCATTGCTCCCTGGACGGGCACGCGGGACCTCCCGGAGTGCCTCCCTGCAACACTTCCCCGCGA
Downstream sequence
CCTTGTATTCCTTCCACAGCCCATTAGCTTAAGGTGATTTCTAACAGTGCATTAGTGTACATTGAATACGGAGTCAAGTTGTTCACTCTATTCAGTGCCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate