Basic Information
VIS ID
TVIS10008950
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2495
Orient
+
Integrated sequence
GACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTT| |ATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGT
Host Sequence
Chromosome
chr5
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
105116297/105780596 (Hg38)
End
105116297/105780596 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA5F
Nearest miRNA
hsa-mir-10397/Upstream/4964031; hsa-mir-103a-1/Downstream/4733233;
Nearest TSS
ENST00000502646/Upstream/387626; ENST00000513676/Downstream/1200273;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/2520747, chr5-CpG: 253/Downstream/1888833
Nearby gene
RAB9BP1(-680498) ; EFNA5(+1596293) ;
Nearest cancer related gene
EFNA5(TSG, +1596293) ;
Upstream sequence
CGGGGCCAAGCTCATTTTTTGTTCAGTTAAGTAAAAGTACATTAGAACttttatcttttttttttttgagacagggtcccactctgttgcccaggctgaa
Downstream sequence
CTAATAAAATCATTATTCTACATAACTATAGTATTTGGTAATTTCATTACTTATAAGCAGTTGAAATTAAATAAATTAAATATCCATGTATTATACAACC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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