HSPA9 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10008956
Fusion event
HBV-HSPA9 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
48
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGC| |CTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTG
Host Sequence
Chromosome
chr5
Cytoband
q31.2
Reference genome
GRCh37/hg19
Start
137896229/138560540 (Hg38)
End
137896229/138560540 (Hg38)
Orient
+
Location type
Intronic
Target gene
HSPA9
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-1226-3p ; hsa-mir-615-3p ; hsa-mir-339-5p ; hsa-mir-324-3p ; hsa-mir-320a ; hsa-mir-302b-5p ; hsa-mir-302d-5p
Nearest miRNA
hsa-mir-10397/Upstream/912891; hsa-mir-103a-1/Downstream/2003131;
Nearest TSS
ENST00000502646/Upstream/1909; ENST00000521941/Downstream/1249;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/16804, chr5-CpG: 67/Downstream/14704
Upstream sequence
TTTAAAAAACTCCAAGCTGTAGTTTTTGCTTAAAAAAAGAATGAAACTTCTTAAAAACAAAAGATCCTGTCAGATTCCATTTTAAAAAGAACAGAACTCC
Downstream sequence
TATCGGGGATACtttttcttcttcttttttttttttttgagacggagtctcgctgtgtcgctcaggctggagtgcggtggcgcaatctccactcaccgca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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