Basic Information
VIS ID
TVIS10008960
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1860
Orient
+
Integrated sequence
TAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCT| |ACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGC
Host Sequence
Chromosome
chr5
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
71146865/71851038 (Hg38)
End
71146865/71851038 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10397/Upstream/12147335; hsa-mir-103a-1/Downstream/318429;
Nearest TSS
ENST00000502646/Upstream/131459; ENST00000504183/Downstream/256196;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/131150, chr5-CpG: 160/Downstream/256012
Nearby gene
CARTPT(-129990) ; MAP1B(+256253) ;
Upstream sequence
agccccggaatttgaggctgcagtaagctgtgtttgcaccattgttctccagcctgggccacacagtgagacttgtctcaaaacaaaacaaaataaaaaC
Downstream sequence
gaaagcgtcgcggttctggcggcatccggtgagctctcgctggcccttgaaaatccgggggagagggtgtaaatctcaacacattcaaaagctagcagaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate