Basic Information
VIS ID
TVIS10008964
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1758
Orient
-
Integrated sequence
AGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAG| |GTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTC
Host Sequence
Chromosome
chr6
Cytoband
q21
Reference genome
GRCh37/hg19
Start
107317661/106996457 (Hg38)
End
107317661/106996457 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA6F
Nearest miRNA
hsa-mir-10398/Upstream/212237; hsa-mir-1202/Downstream/12072590;
Nearest TSS
ENST00000381078/Upstream/20830; ENST00000489790/Downstream/31756;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/20579, chr6-CpG: 44/Downstream/31615
Nearby gene
LINC02532(-82361) ; C6orf203(+31746) ;
Upstream sequence
TAGTAAATGTCTGCTTGGTTAATGACATATTAATGAGTTTTTAAGACCGTCATATCATTTACCATAAAAGACCCATGTGCCTATCCCTGGATGTACTGTA
Downstream sequence
tattgttgcccaggctgcagtgcaatggcacaatcttggctcactgcaacctctgcctcctgggttcaagtgattctcctacctcagccccctgagtagc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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