Basic Information
VIS ID
TVIS10008968
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1831
Orient
+
Integrated sequence
CTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACC| |TCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGG
Host Sequence
Chromosome
chr6
Cytoband
q27
Reference genome
GRCh37/hg19
Start
165236314/164822825 (Hg38)
End
165236314/164822825 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10398/Upstream/6058072; hsa-mir-1913/Downstream/1686529;
Nearest TSS
ENST00000381078/Upstream/474181; ENST00000456118/Downstream/4925;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/485478, chr6-CpG: 31/Downstream/511449
Nearby gene
QKI(-1236686) ; C6orf118(+456839) ;
Upstream sequence
TGCTTAGACCTATGTAGGCTGTATCCCCTCAGTGTGGGCTTGTCTCTCAGTAGGAACTTCTAATTGAGTGTTTTGTGCATTTGACTGAAAGAGTCTCATT
Downstream sequence
gtgtacgaaaaaatagaatgagctgggcgcggtggctcacgcctgtaatcccagcactttgggaggccaaggcaggtggatcacctgaggtcaggagttc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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