Basic Information
VIS ID
TVIS10008971
Fusion event
HBV-GMDS-DT integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2035
Orient
+
Integrated sequence
ACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTC| |CTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGA
Host Sequence
Chromosome
chr6
Cytoband
p25.3
Reference genome
GRCh37/hg19
Start
2263423/2263189 (Hg38)
End
2263423/2263189 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
GMDS-DT
Nearest miRNA
hsa-mir-6720/Upstream/872778; hsa-mir-10398/Downstream/590842;
Nearest TSS
ENST00000381078/Upstream/17334; ENST00000534160/Downstream/43104;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/17270, chr6-CpG: 53/Downstream/370949
Upstream sequence
tttttttttttttgagatgaagtttcactcttgttgcccaggctgcagtgtaatggcacgatctctgctcactgcaacctctgtctcccaggttcaagcc
Downstream sequence
taattacttataagggccaggaggtttttggagattcttctgaattgtctatgtagatgattgtgtcatctatgaacaaagacagttttatttctttctt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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