VISDB Viral Integration Site DataBase

VIS ID

TVIS10008972

Fusion event

HBV-MRS2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|Polymerase|

Start

2425

Orient

+

Integrated sequence

ACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAA| |GATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTC

Chromosome

chr6

Cytoband

p22.3

Reference genome

Start

End

24419623/24419395 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-155-5p ; hsa-mir-98-5p ; hsa-mir-744-5p ; hsa-mir-20a-5p ; hsa-let-7a-5p ; hsa-mir-607 ; hsa-mir-1263 ; hsa-mir-150-3p ; hsa-mir-6715b-3p ; hsa-mir-544a ; hsa-mir-5047 ; hsa-mir-1301-3p ; hsa-mir-642a-5p ; hsa-mir-4660 ; hsa-mir-26b-3p ; hsa-mir-17-3p ; hsa-mir-1205 ; hsa-mir-1184 ; hsa-mir-3158-5p ; hsa-mir-6892-3p ; hsa-mir-2276-5p ; hsa-mir-5197-5p ; hsa-mir-92b-3p ; hsa-mir-32-5p ; hsa-mir-92a-3p

Nearest miRNA

hsa-mir-3691/Upstream/5847515; hsa-mir-10398/Downstream/2728231;

Nearest TSS

Nearest CpG islands

None/Target, chr6-CpG: 120/Upstream/15937, chr6-CpG: 98/Downstream/75041

Upstream sequence

TCTAGGAAGAGGCAAACTACAAACTACTAGGATTCTGATTTCAGATGTAGTCATTCCAGAACCTTCTCTTTATGAGTTCACCTGCTAGTACAATCTCCAC

Downstream sequence

ATGGGAAAGGTGTGATAAAACAGTGTCTCTGTGAAGCAGTGTTAATGAagagtttttattttttaattcttacatgtctggcaacgtaccaggcggtttg