VISDB Viral Integration Site DataBase

VIS ID

TVIS10008973

Fusion event

HBV-HIST1H2AE integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1768

Orient

-

Integrated sequence

TGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTC| |TTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCA

Chromosome

chr6

Cytoband

p22.2

Reference genome

Start

End

26217267/26217039 (Hg38)

Orient

-

Location type

Exonic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-34a-5p ; hsa-mir-365a-5p ; hsa-mir-940 ; hsa-mir-221-3p ; hsa-mir-92a-3p ; hsa-mir-5693 ; hsa-mir-659-3p ; hsa-mir-29b-2-5p ; hsa-mir-8057 ; hsa-mir-4314 ; hsa-mir-6822-3p ; hsa-mir-4766-5p ; hsa-mir-146a-3p ; hsa-mir-1276 ; hsa-mir-760 ; hsa-mir-9-5p ; hsa-mir-3661 ; hsa-mir-6748-5p ; hsa-mir-6769b-5p ; hsa-mir-6769a-5p ; hsa-mir-4483 ; hsa-mir-1293 ; hsa-mir-6766-5p ; hsa-mir-6756-5p ; hsa-mir-6745 ; hsa-mir-363-5p ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-3192-5p ; hsa-mir-4646-5p ; hsa-mir-204-3p

Nearest miRNA

hsa-mir-3691/Upstream/7645159; hsa-mir-10398/Downstream/930587;

Nearest TSS

Nearest CpG islands

chr6-CpG: 32/Target, None/Upstream, None/Downstream

Upstream sequence

AGCAAAAGGTCTCATAGATCAAGAgaaaaaaacaagcaaaggggagaggattccctatttattaatggtgctgggagaactggctagccatatacagaaa

Downstream sequence

CGGTCTTCAGTTTCCAGTTGGCCGTGTGCACCGCCTCCTCCGCAAAGGCAACTACTCCGAACGAGTCGGGGCCGGCGCTCCAGTGTACCTGGCAGCGGTG