Basic Information
VIS ID
TVIS10008977
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1826
Orient
-
Integrated sequence
AAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTT| |TCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAA
Host Sequence
Chromosome
chr6
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
76245908/75536192 (Hg38)
End
76245908/75536192 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA6D
Nearest miRNA
hsa-mir-10398/Upstream/107719; hsa-mir-10524/Downstream/3003071;
Nearest TSS
ENST00000381078/Upstream/42454; ENST00000493959/Downstream/65317;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/251074, chr6-CpG: 121/Downstream/65422
Nearby gene
FILIP1(-42412) ; SENP6(+65714) ;
Upstream sequence
gagacagatgccttcctcttgtctcaactgcaagaggcattccttcctcttttactaatcctcctcagcacagaccctttacgggtgtcaggctggggga
Downstream sequence
TTCTACATTTTACATGAAGCAGCCACCaaaaataataataacataataataataaCATGAAGTGGTTAGCTAAACAGTaataaataaataaataaataaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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