Basic Information
VIS ID
TVIS10008978
Fusion event
HBV-MEI4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2876
Orient
+
Integrated sequence
TTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAAT| |CCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAG
Host Sequence
Chromosome
chr6
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
78455320/77745603 (Hg38)
End
78455320/77745603 (Hg38)
Orient
-
Location type
Intronic
Target gene
MEI4
Nearest miRNA
hsa-mir-10398/Upstream/2317130; hsa-mir-10524/Downstream/793660;
Nearest TSS
ENST00000381078/Upstream/54945; ENST00000607739/Downstream/860433;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/94976, chr6-CpG: 46/Downstream/1121838
Nearby gene
HTR1B(-282200) ; IRAK1BP1(+1121869) ;
Upstream sequence
TGCCCAGTACTATTTAACTATATCAGTCTCCTTGCTTGGAATTTAATGGTCATCAGTTGCATTAGTCAATTTTTATTGCTCTTTGAATTATGTACACTGC
Downstream sequence
tctgcaccaagcagacataatagacatctacagaactctccaccccaaatcaacagaatatacatttttttcagcaccacaccacacctattccaaaatt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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