Basic Information
VIS ID
TVIS10008979
Fusion event
HBV-LOC100506207 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1771
Orient
-
Integrated sequence
ACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTT| |GTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGC
Host Sequence
Chromosome
chr6
Cytoband
p24.3
Reference genome
GRCh37/hg19
Start
8638315/8638082 (Hg38)
End
8638315/8638082 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
LOC100506207
Nearest miRNA
hsa-mir-3691/Upstream/2468647; hsa-mir-10398/Downstream/1801635;
Nearest TSS
ENST00000381078/Upstream/202471; ENST00000645232/Downstream/523695;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/202174, chr6-CpG: 41/Downstream/760778
Upstream sequence
tttttttttttttgtatttttagtagagatgggatttcatcatgttggccaggctgatctcaaactccagacctcaggtgatccacctgccttggcttcc
Downstream sequence
TGGATGTACTGTATAATTAAGTAATGTGGCCCAGAGGAGTTAATCATTTAAAACCCTGTCATCTTTCTCAAGTTTGCAGATAGAAGAGCTAGCACAGAAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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