VISDB Viral Integration Site DataBase

VIS ID

TVIS10008982

Fusion event

HBV-RASA4 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1757

Orient

-

Integrated sequence

AAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTA| |GGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGT

Chromosome

chr7

Cytoband

q22.1

Reference genome

Start

End

102226504/102586057 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-218-5p ; hsa-mir-4314 ; hsa-mir-7155-5p ; hsa-mir-637 ; hsa-mir-8089 ; hsa-mir-4700-5p ; hsa-mir-4667-5p ; hsa-mir-660-3p ; hsa-mir-5193 ; hsa-mir-483-3p ; hsa-mir-330-3p ; hsa-mir-1273e ; hsa-mir-1273h-5p ; hsa-mir-149-3p ; hsa-mir-1827 ; hsa-mir-1910-3p ; hsa-mir-219b-3p ; hsa-mir-2467-3p ; hsa-mir-302f ; hsa-mir-30b-3p ; hsa-mir-3123 ; hsa-mir-31-5p ; hsa-mir-3192-5p ; hsa-mir-3612 ; hsa-mir-3689a-3p ; hsa-mir-3689b-3p ; hsa-mir-3689c ; hsa-mir-377-5p ; hsa-mir-3929 ; hsa-mir-4257 ; hsa-mir-4419b ; hsa-mir-4478 ; hsa-mir-455-3p ; hsa-mir-4649-3p ; hsa-mir-4728-5p ; hsa-mir-485-5p ; hsa-mir-490-3p ; hsa-mir-6086 ; hsa-mir-6499-3p ; hsa-mir-650 ; hsa-mir-6511a-5p ; hsa-mir-6516-5p ; hsa-mir-665 ; hsa-mir-6771-5p ; hsa-mir-6779-5p ; hsa-mir-6780a-5p ; hsa-mir-6785-5p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6884-5p ; hsa-mir-7106-5p ; hsa-mir-7160-5p ; hsa-mir-7851-3p ; hsa-mir-2909 ; hsa-mir-3162-5p ; hsa-mir-4775 ; hsa-mir-590-3p

Nearest miRNA

hsa-mir-10525/Upstream/114526; hsa-mir-10399/Downstream/12067288;

Nearest TSS

Nearest CpG islands

None/Target, chr7-CpG: 39/Upstream/13242, chr7-CpG: 20/Downstream/6823

Upstream sequence

tttactgatggacatgaaagtgctaagttagcccagagagttgcaaaggtctcagatgcagtgttctctgccaccactgtgtagcagcaaaacactttcc

Downstream sequence

gttgcctaggctcgtctctaactcctgagctcaggcaatccgcctaccttggcctcccaaagtgctaggattacaggcgtgagccaccacacccggccaa