Basic Information
VIS ID
TVIS10008983
Fusion event
HBV-LOC105375451 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2327
Orient
+
Integrated sequence
CTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAAC| |ACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGA
Host Sequence
Chromosome
chr7
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
110157970/110517913 (Hg38)
End
110157970/110517913 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105375451
Nearest miRNA
hsa-mir-10525/Upstream/8046382; hsa-mir-10399/Downstream/4135432;
Nearest TSS
ENST00000635602/Upstream/920747; ENST00000464835/Downstream/16841;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/1947451, chr7-CpG: 68/Downstream/1044110
Nearby gene
EIF3IP1(-557700) ; IMMP2L(+145136) ;
Upstream sequence
TTGGTGACACATGGAGGCACTGATTGTTTCCTAAGGGCTCTTTTACGAGATCTCCAATAAAGTTCTAAGCGGATCATGCCTGTTTGGGGAAAGATAACAC
Downstream sequence
actgtaacctctgcctctgcctcctgagtagctgggactacaggcatgtgccaccatgcctggctaatttttgtgttttttttcagcagagacagggttt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate