VISDB Viral Integration Site DataBase

VIS ID

TVIS10008985

Fusion event

HBV-FOXP2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

2134

Orient

+

Integrated sequence

CCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAG| |ATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGG

Chromosome

chr7

Cytoband

q31.1

Reference genome

Start

End

113903816/114263761 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-95-5p ; hsa-mir-3613-3p ; hsa-mir-548p ; hsa-mir-4422 ; hsa-mir-6835-3p ; hsa-mir-190a-5p ; hsa-mir-1273h-3p ; hsa-mir-129-5p ; hsa-mir-2467-3p ; hsa-mir-3678-3p ; hsa-mir-3680-3p ; hsa-mir-450b-5p ; hsa-mir-507 ; hsa-mir-557 ; hsa-mir-6516-5p

Nearest miRNA

hsa-mir-10525/Upstream/11792230; hsa-mir-10399/Downstream/389584;

Nearest TSS

Nearest CpG islands

None/Target, chr7-CpG: 39/Upstream/176021, chr7-CpG: 61/Downstream/658354

Upstream sequence

GATAACAAGTCACAATCAGGGGGTCCTTTTCCTACTTTTAATACTAACTAAGTATGACTGTACCTTCCTGGGAACCTGCATAGAGCAAAAAGAAAACCTT

Downstream sequence

GCAAGAAAGAAAATACAGGCATTTTAAAGGAACCATAACAGTTATACTGGTATACACTCTGTCGGCCTCGAGCTGGCTTCTAGTTTGCATTCCCATGCTT