Basic Information
VIS ID
TVIS10008988
Fusion event
HBV-POT1-AS1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1841
Orient
+
Integrated sequence
TTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAAT| |CATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTG
Host Sequence
Chromosome
chr7
Cytoband
q31.33
Reference genome
GRCh37/hg19
Start
124688587/125048533 (Hg38)
End
124688587/125048533 (Hg38)
Orient
+
Location type
Intronic
Target gene
POT1-AS1
Nearest miRNA
hsa-mir-10525/Upstream/8028214; hsa-mir-10399/Downstream/2009555;
Nearest TSS
ENST00000635602/Upstream/55525; ENST00000424515/Downstream/105078;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/118388, chr7-CpG: 237/Downstream/2202713
Nearby gene
POT1(-118550) ; GRM8(+1390065) ;
Upstream sequence
TACTTCTCTAGGGAGATGAACTCTAAAATCTTGTTTCTGGGAGATACTGCAATTTGTGGTCTCAGATTCTAGACTATTCCAAAGAAAGCTCTCTGAGCTC
Downstream sequence
ggtgtgctgtatttgggagacccatctcatgtgcaaagacactcatgggctcaaaataaaaagaaaagtggaggaagatttaccaagcaaatggaaagca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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