VISDB Viral Integration Site DataBase

VIS ID

TVIS10008990

Fusion event

HBV-MKLN1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|Polymerase|

Start

1606

Orient

+

Integrated sequence

CGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGT| |CGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCAT

Chromosome

chr7

Cytoband

q32.3

Reference genome

Start

End

131008263/131323504 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-128-3p ; hsa-mir-124-3p ; hsa-mir-101-3p ; hsa-mir-27a-3p ; hsa-mir-320b ; hsa-mir-324-5p ; hsa-mir-100-5p ; hsa-mir-142-3p ; hsa-mir-16-1-3p ; hsa-mir-144-3p ; hsa-mir-376c-5p ; hsa-mir-376b-5p ; hsa-mir-513a-5p ; hsa-mir-651-3p ; hsa-mir-1252-5p ; hsa-mir-3165 ; hsa-mir-5002-5p ; hsa-mir-6880-5p ; hsa-mir-8071 ; hsa-mir-142-5p ; hsa-mir-5590-3p ; hsa-mir-4496 ; hsa-mir-511-3p ; hsa-mir-297 ; hsa-mir-3924 ; hsa-mir-155-5p ; hsa-mir-5191 ; hsa-mir-3681-3p ; hsa-mir-216a-3p ; hsa-mir-3154 ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-340-5p ; hsa-mir-8054 ; hsa-mir-548l ; hsa-mir-548k ; hsa-mir-548av-5p ; hsa-mir-559 ; hsa-mir-548y ; hsa-mir-548w ; hsa-mir-548o-5p ; hsa-mir-548j-5p ; hsa-mir-548i ; hsa-mir-548h-5p ; hsa-mir-548d-5p ; hsa-mir-548c-5p ; hsa-mir-548b-5p ; hsa-mir-548bb-5p ; hsa-mir-548ay-5p ; hsa-mir-548au-5p ; hsa-mir-548as-5p ; hsa-mir-548ar-5p ; hsa-mir-548aq-5p ; hsa-mir-548ap-5p ; hsa-mir-548am-5p ; hsa-mir-548ak ; hsa-mir-548ae-5p ; hsa-mir-548ad-5p ; hsa-mir-548ab ; hsa-mir-548a-5p ; hsa-mir-548c-3p ; hsa-mir-5698 ; hsa-mir-744-3p ; hsa-mir-6805-3p ; hsa-mir-5691 ; hsa-mir-4423-5p ; hsa-mir-6501-5p ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-3194-3p ; hsa-mir-6499-3p ; hsa-mir-367-5p ; hsa-mir-1267 ; hsa-mir-6733-3p ; hsa-mir-143-5p ; hsa-mir-106a-3p ; hsa-mir-8055 ; hsa-mir-374b-3p ; hsa-mir-539-3p ; hsa-mir-485-3p ; hsa-mir-889-3p ; hsa-mir-548au-3p ; hsa-mir-449b-5p ; hsa-mir-449a ; hsa-mir-34c-5p ; hsa-mir-34a-5p ; hsa-mir-3140-3p ; hsa-mir-4686 ; hsa-mir-575 ; hsa-mir-4676-5p ; hsa-mir-6858-3p ; hsa-mir-3529-3p ; hsa-mir-5583-3p ; hsa-mir-4517

Nearest miRNA

hsa-mir-10525/Upstream/445965; hsa-mir-10399/Downstream/1711356;

Nearest TSS

Nearest CpG islands

None/Target, chr7-CpG: 39/Upstream/215490, chr7-CpG: 74/Downstream/4197

Upstream sequence

ttatttctttaccatttgttctctttattctttgtttctctgtttcctagcttctgccttattttgaattatttgaataatttttaatattccacttcag

Downstream sequence

tatcaaaagatccccatttttggtcattgttgcctatgatcattccaggttagatgggtctactttcccagatactacaagacagtaccccataaatcat