Basic Information
VIS ID
TVIS10008993
Fusion event
HBV-DPY19L2P3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1900
Orient
+
Integrated sequence
CTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGG| |GCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATAC
Host Sequence
Chromosome
chr7
Cytoband
p14.3
Reference genome
GRCh37/hg19
Start
29778797/29739181 (Hg38)
End
29778797/29739181 (Hg38)
Orient
-
Location type
Intronic
Target gene
DPY19L2P3
Nearest miRNA
hsa-mir-1183/Upstream/58353; hsa-mir-10399/Downstream/550613;
Nearest TSS
ENST00000635602/Upstream/173731; ENST00000409123/Downstream/67305;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/53361, chr7-CpG: 101/Downstream/67084
Nearby gene
DPY19L2P3(-50938) ; WIPF3(+67373) ;
Upstream sequence
CCAAAGAGCTCCTAGAAAATAAAGACAAAGCCTAAGGATCAGATACATCTTGAGACTGATAGAGAATTCCAGAAGTTTCTCTCCTTCAGTACTTTATTGT
Downstream sequence
tgtgcaagtggagtttatcccaggaatgcaaagttgtctcactatttgaaaaccaatcaggtgaattcaccacagtaacaaactgaaaaagaaagaccgc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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