Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10008996
Fusion event
HBV-AOAH integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
X protein|
Start
1776
Orient
+
Integrated sequence
CAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACT| |AGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCA
Host Sequence
Chromosome
chr7
Cytoband
p14.2
Reference genome
Start
End
36587759/36548153 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
Target gene
Nearest miRNA
hsa-mir-1183/Upstream/1607319; hsa-mir-10399/Downstream/371204;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/157956, chr7-CpG: 136/Downstream/899598
Upstream sequence
GATAGTAATCAGACAACAGAGGCTTCAGTTGTGAGAGTTAGAATCTGAGAAACAAGCTCCAGGTACACAGGATAGGAAATCTGGGCTGGAGAGCAGCTTG
Downstream sequence
GACAGATTGGTACTGTTGATTTCACACGTGTCTAGGACTTGCttttttttgagatagagtcttgctccgtcgctcaggctggagtgcagtggcacgatct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.