Basic Information
VIS ID
TVIS10009000
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
857
Orient
+
Integrated sequence
GGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTTACCAATTTTCTTTTGTCTTTGGGTATACATTTAAACCCTAACAAAACAAAGAGA| |TGGGGTTACTCTCTAAATTTTATGGGTTATGTCATTGGATGTTATGGGTCCTTGCCACAAGAACACATCATACAAAAAATCAAAGAATGTTTTAGAAAAC
Host Sequence
Chromosome
chr7
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
98106293/98476981 (Hg38)
End
98106293/98476981 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA7F
Nearest miRNA
hsa-mir-10525/Upstream/512500; hsa-mir-10399/Downstream/404669;
Nearest TSS
ENST00000635602/Upstream/75913; ENST00000466102/Downstream/140316;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/6004, chr7-CpG: 219/Downstream/139512
Nearby gene
BAIAP2L1(-75866) ; NPTX2(+140304) ;
Nearest cancer related gene
BAIAP2L1(OG, -75866) ;
Upstream sequence
Atttttttttttttttttttttttttttgagacggagtcccgctgtttagcccaggccggattgcagtggcgcaatctcggctcactgcaagctccgcct
Downstream sequence
CCAGGAGTTTCTCAGAAGAAATTCTAGCTGGATGAGCATTTAAGGAAGGAGATGAAGTCAGCGTTTGGAGACAATGAATTAGATGGCTGGATATGTCACC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate