VISDB Viral Integration Site DataBase

VIS ID

TVIS10009005

Fusion event

HBV-MTSS1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|

Start

1156

Orient

-

Integrated sequence

TGCCTTTGTATGCATGTATTCAATCTAAGCAGGCTTTCACTTTCTCGCCAACTTACAAGGCCTTTCTGTGTAAACAATACCTGAACCTTTACCCCGTTGC| |CCGGCAACGGCCAGGTCTGTGCCAAGTGTTTGCTGACGCAACCCCCACTGGCTGGGGCTTGGTCATGGGCCATCAGCGCATGCGTGGAACCTTTTCGGCT

Chromosome

chr8

Cytoband

q24.13

Reference genome

Start

End

125566763/124554522 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

FRA8C ; FRA8E

Target gene

miRNAs that regulate target gene

hsa-mir-182-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-135a-5p ; hsa-mir-7111-3p ; hsa-mir-676-5p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183 ; hsa-mir-5193 ; hsa-mir-33a-3p ; hsa-mir-7-2-3p ; hsa-mir-7-1-3p ; hsa-mir-96-5p ; hsa-mir-15b-5p

Nearest miRNA

hsa-mir-12123/Upstream/45946; hsa-mir-10400/Downstream/267456;

Nearest TSS

Nearest CpG islands

None/Target, chr8-CpG: 109/Upstream/15242, chr8-CpG: 161/Downstream/172922

Nearest cancer related gene

MTSS1(TSG, No orient, 0)

Upstream sequence

ttttttaaaaataaaaagaataaaatacaaaatatGGTATTCTTATGAGAACATCATTCAAGAACAACATTAGGATCATCTAATTAATACTCTGATCTGA

Downstream sequence

AGCTTTTGGTCAATTATCATAGATATATTCTAGCTGTTAGATTTTCATCTTGCCTGACTTGTGTGTGCAGTGGACTTGAGGATGAAGGAGGCAGGTTTGA