Basic Information
VIS ID
TVIS10009007
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2125
Orient
+
Integrated sequence
TTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTA| |ATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCT
Host Sequence
Chromosome
chr8
Cytoband
q24.13
Reference genome
GRCh37/hg19
Start
126923291/125911047 (Hg38)
End
126923291/125911047 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA8C ; FRA8E
Nearest miRNA
hsa-mir-12123/Upstream/1088989; hsa-mir-10400/Downstream/1884915;
Nearest TSS
ENST00000518652/Upstream/160806; ENST00000500180/Downstream/40103;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/478849, chr8-CpG: 180/Downstream/645384
Nearby gene
TRIB1(-472647) ; LINC00861(+11476) ;
Nearest cancer related gene
TRIB1(OG, -472647) ;
Upstream sequence
aggagctgatgaacatgggaagataaagagtaatagggTGAAGCGATTAATTGgtacaggtttttcatgaacttaattttcatttctctgggataatgtc
Downstream sequence
aactcgggaggtggaggttgtggtgagctgagattgtgccatcgcactccagctaggcaacaagagtgaaactccgtctcaaaaaaaaTAAaaaataaaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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