Basic Information
VIS ID
TVIS10009009
Fusion event
HBV-LOC105379371 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1861
Orient
+
Integrated sequence
AAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTA| |CTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCC
Host Sequence
Chromosome
chr8
Cytoband
p12
Reference genome
GRCh37/hg19
Start
36102849/36245331 (Hg38)
End
36102849/36245331 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105379371
Nearest miRNA
hsa-mir-124-1/Upstream/6287983; hsa-mir-10400/Downstream/5025717;
Nearest TSS
ENST00000518652/Upstream/150285; ENST00000522417/Downstream/533833;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/1008738, chr8-CpG: 351/Downstream/1449095
Nearby gene
UNC5D(-450668) ; KCNU1(+538993) ;
Upstream sequence
CAAGTTACCAGCAGGGAAGGGCCTCGCTGATTAAAATAAAGCACAAACCACTTTCCCCTCCACCATGAGAGAGACCTGCTAGAAGGGGTTATTACACCTT
Downstream sequence
atttaaattgaaaggcacagacagattgaaatttaaaagatggaaaatgatatacatgcaaacggtaaccagaagaaagctgaagtacctatattaaaag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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