Basic Information
VIS ID
TVIS10009010
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|
Start
1875
Orient
+
Integrated sequence
TAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCC| |AAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTC
Host Sequence
Chromosome
chr8
Cytoband
p11.21
Reference genome
End
41342034/41484515 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-124-1/Upstream/213372; hsa-mir-10400/Downstream/175926;
Nearby gene
SFRP1(-175044) ; GOLGA7(+6047) ;
Nearest cancer related gene
SFRP1(TSG, -175044) ;
Upstream sequence
TAGTCCAAGTAATTATATGTAACGTAAAATTACATACAGCACAGTCATCAAAGAAGCTGTCCTTCCTTCCCCTATCACTAAGATCTAGGGTGACTCTGGA
Downstream sequence
gattacaggggcatgccactacctcgggctaatttttgtatttttagtagagacgaggtttcaccatgttggccaggctggtctccgactcctgacttcg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate