Basic Information
VIS ID
TVIS10009011
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
629
Orient
-
Integrated sequence
TGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTT| |CGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGG
Host Sequence
Chromosome
chr8
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
41342064/41484545 (Hg38)
End
41342064/41484545 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-124-1/Upstream/213402; hsa-mir-10400/Downstream/175896;
Nearest TSS
ENST00000518652/Upstream/49247; ENST00000523420/Downstream/5851;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/174924, chr8-CpG: 69/Downstream/5730
Nearby gene
SFRP1(-175074) ; GOLGA7(+6017) ;
Nearest cancer related gene
SFRP1(TSG, -175074) ;
Upstream sequence
atatatatatacacacacatatatatgtatatatatatacatatatatgtaGAgtgtgtgtgtgtgtgtgcatgtgtgtgtgtCACAGATCTAAATTAGA
Downstream sequence
aatttttgtatttttagtagagacgaggtttcaccatgttggccaggctggtctccgactcctgacttcgtgatctgcttgcctcggccccccaaagtgc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate