Basic Information
VIS ID
TVIS10009014
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
397
Orient
-
Integrated sequence
TGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTA| |TCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTC
Host Sequence
Chromosome
chr8
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
67402113/66489878 (Hg38)
End
67402113/66489878 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-124-1/Upstream/2110621; hsa-mir-10400/Downstream/8058665;
Nearest TSS
ENST00000518652/Upstream/16000; ENST00000488582/Downstream/3330;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/50274, chr8-CpG: 29/Downstream/15475
Nearby gene
ADHFE1(-21069) ; VXN(+3378) ;
Upstream sequence
gagacagatgccttcctcttgtctcaactgcaagaggcattccttcctcttttactaatcctcctcagcacagaccctttacgggtgtcaggctggggga
Downstream sequence
tttattttattttgtagagaggtcttgatgtgttgcccaggctggtctcaaactcttggcctcaagtgatcctcccacctcaacctcccaaagtgctggg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate