Basic Information
VIS ID
TVIS10009015
Fusion event
HBV-LOC105376188 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1780
Orient
-
Integrated sequence
AATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGA| |GGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCT
Host Sequence
Chromosome
chr9
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
105020003/102257721 (Hg38)
End
105020003/102257721 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105376188
Nearest miRNA
hsa-let-7a-1/Upstream/4028504; hsa-mir-12126/Downstream/4343207;
Nearest TSS
ENST00000422679/Upstream/519141; ENST00000374801/Downstream/261915;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/518927, chr9-CpG: 38/Downstream/1741628
Nearby gene
GRIN3A(-519141) ; CYLC2(+737590) ;
Upstream sequence
ACTTGCACAAACATTTTCAGTAGTTTGTATTTAGTTAAAAATTTCATCTCTGCAATAAAGTTCAGCAATCTATGTGGAAGCTTGGTGTGTCTTAAACTCA
Downstream sequence
ccaccagcaatgtaaaagtgttcccttttcaccacatccatgccaacatctattattttttattatggccactcttgcagtagtaacatggtatcacatt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate