VISDB Viral Integration Site DataBase

VIS ID

TVIS10009016

Fusion event

HBV-RPS6 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1817

Orient

-

Integrated sequence

TGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCAT| |GCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCT

Chromosome

chr9

Cytoband

p22.1

Reference genome

Start

End

19378878/19378880 (Hg38)

Orient

+

Location type

Exonic

Target gene

miRNAs that regulate target gene

hsa-mir-16-5p ; hsa-mir-744-5p ; hsa-mir-652-3p ; hsa-mir-15b-5p ; hsa-mir-182-3p ; hsa-mir-99a-5p ; hsa-let-7d-5p ; hsa-mir-1260b ; hsa-mir-544a ; hsa-mir-6878-3p ; hsa-mir-3187-3p ; hsa-mir-640 ; hsa-mir-378a-5p ; hsa-mir-6744-3p ; hsa-mir-4757-5p ; hsa-mir-4529-5p ; hsa-mir-4312 ; hsa-mir-6778-3p ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-3190-5p ; hsa-mir-3653-5p ; hsa-mir-212-5p ; hsa-mir-6747-3p ; hsa-mir-4286 ; hsa-mir-1224-3p ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-6765-3p

Nearest miRNA

hsa-mir-101-2/Upstream/805501; hsa-let-7a-1/Downstream/1032268;

Nearest TSS

Nearest CpG islands

None/Target, chr9-CpG: 64/Upstream/147560, chr9-CpG: 48/Downstream/916

Upstream sequence

ATTTAGTTAAAAATTTCATCTCTGCAATAAAGTTCAGCAATCTATGTGGAAGCTTGGTGTGTCTTAAACTCAGATTTATAAATGCTTGTCACACCAATAA

Downstream sequence

TGTTTGTCGTTCCCACCACTGATTCGGACCACATAACCCTGCAAGAGCATACAATGAATGACACATTTACTATTTCTATTCCAAAATTATACAGTACAGG