Basic Information
VIS ID
TVIS10009020
Fusion event
HBV-RIC1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1827
Orient
-
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr9
Cytoband
p24.1
Reference genome
GRCh37/hg19
Start
5764645/5764645 (Hg38)
End
5764645/5764645 (Hg38)
Orient
+
Location type
Intronic
Target gene
RIC1
miRNAs that regulate target gene
hsa-mir-103a-3p ; hsa-mir-16-5p
Nearest miRNA
hsa-mir-101-2/Upstream/914270; hsa-let-7a-1/Downstream/243181;
Nearest TSS
ENST00000422679/Upstream/1248; ENST00000490816/Downstream/5561;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/134902, chr9-CpG: 88/Downstream/67934
Upstream sequence
aagaattctgacaaacttctttgtgatgtgtgctgtcatctcacagatttgaaaatttcttttgattcatcagtttggaaacactctttttgttgaatct
Downstream sequence
AGACACTCAAGCAGAGGCCAGGTGGCCTTGAAGTATGATTCCATGGCTAACCCTAAAGAAAAAGACATAGGGTTTTAAAAATAGAATCAAAATAAATGCA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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