Basic Information
VIS ID
TVIS10009021
Fusion event
HBV-RIC1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2200
Orient
+
Integrated sequence
ACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAAC| |TCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAG
Host Sequence
Chromosome
chr9
Cytoband
p24.1
Reference genome
GRCh37/hg19
Start
5764680/5764680 (Hg38)
End
5764680/5764680 (Hg38)
Orient
-
Location type
Intronic
Target gene
RIC1
miRNAs that regulate target gene
hsa-mir-103a-3p ; hsa-mir-16-5p
Nearest miRNA
hsa-mir-101-2/Upstream/914305; hsa-let-7a-1/Downstream/243146;
Nearest TSS
ENST00000422679/Upstream/1283; ENST00000490816/Downstream/5526;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/134937, chr9-CpG: 88/Downstream/67899
Upstream sequence
agtgacaatgggctggggtccccttccatgctgtggaagctttgttcttttgctcttcacaataaatattgctgctgctcactgtttgggtccgtgccat
Downstream sequence
TGATTCCATGGCTAACCCTAAAGAAAAAGACATAGGGTTTTAAAAATAGAATCAAAATAAATGCAGCTGTTTTTTGGTTCCGGGTCACTCCCTGCAACTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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