VISDB Viral Integration Site DataBase

VIS ID

TVIS10009026

Fusion event

HBV-APBA1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

716

Orient

+

Integrated sequence

CATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTC| |CCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTTACCAATTTTCTTT

Chromosome

chr9

Cytoband

q21.12

Reference genome

Start

End

72161247/69546331 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-450a-1-3p ; hsa-mir-7977 ; hsa-mir-8059 ; hsa-mir-4471 ; hsa-mir-1292-5p ; hsa-mir-6774-5p ; hsa-mir-635 ; hsa-mir-3667-3p ; hsa-mir-6734-3p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-2114-5p ; hsa-mir-212-3p ; hsa-mir-132-3p ; hsa-mir-3199 ; hsa-mir-365a-5p ; hsa-mir-365b-5p ; hsa-mir-574-5p ; hsa-mir-6818-5p ; hsa-mir-6867-5p ; hsa-mir-8052 ; hsa-mir-892a

Nearest miRNA

hsa-mir-101-2/Upstream/28312496; hsa-let-7a-1/Downstream/1263644;

Nearest TSS

Nearest CpG islands

None/Target, chr9-CpG: 64/Upstream/29073, chr9-CpG: 123/Downstream/125557

Upstream sequence

aagggttagggtgagggtgagggtgagggttagggttaggggttagtgttggggttggggttagggttttagagttagggttagggttagggttagggtt

Downstream sequence

CCAGAGATATGTTGTGGGTTGCTTTTCCTGCCCACAGTTCCATTTCTGTAGGAACTGTTCCCACTCAGGGACTCTGCCTGAGCTGCCATGATTTAATTAG