VISDB Viral Integration Site DataBase

VIS ID

TVIS10009027

Fusion event

HBV-PTPRD integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

2026

Orient

-

Integrated sequence

TTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCT| |TAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAA

Chromosome

chr9

Cytoband

p24.1

Reference genome

Start

End

8929700/8929700 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-429 ; hsa-mir-200a-3p ; hsa-mir-200c-3p ; hsa-mir-141-3p ; hsa-mir-1-3p ; hsa-mir-200b-3p ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-374b-3p ; hsa-mir-3924 ; hsa-mir-340-5p ; hsa-mir-4524b-5p ; hsa-mir-4791 ; hsa-mir-4524a-5p ; hsa-mir-3201 ; hsa-mir-891b ; hsa-mir-1246 ; hsa-mir-8076 ; hsa-mir-3163 ; hsa-mir-646 ; hsa-mir-5583-3p ; hsa-mir-503-5p ; hsa-mir-424-5p ; hsa-mir-15a-5p ; hsa-mir-497-5p ; hsa-mir-6838-5p ; hsa-mir-15b-5p ; hsa-mir-16-5p ; hsa-mir-195-5p ; hsa-mir-135a-5p

Nearest miRNA

hsa-mir-101-2/Upstream/2921796; hsa-let-7a-1/Downstream/9643606;

Nearest TSS

Nearest CpG islands

None/Target, chr9-CpG: 64/Upstream/70992, chr9-CpG: 76/Downstream/1682935

Nearest cancer related gene

PTPRD(TSG, No orient, 0)

Upstream sequence

TGCCTGGTAGGCAGAATAACTACCTTAATTTTTCAAGGTGATTAAGCTGATTAAGTAAGAACACTGTGATTCTTCATTCATTCGTCTTCACTTAACCAGA

Downstream sequence

atgtgtatatatatatgtgtatatatatatgtgtatatatatgtgtatatatatatgtatatatatgtgtatatatatgggtgtgtatatatgtgtgtgt