Basic Information
VIS ID
TVIS10009032
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
182
Orient
+
Integrated sequence
CAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCT| |AGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTA
Host Sequence
Chromosome
chrX
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
78307978/79052481 (Hg38)
End
78307978/79052481 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7f-2/Upstream/151232; hsa-mir-105-1/Downstream/5173271;
Nearest TSS
ENST00000429181/Upstream/107060; ENST00000276077/Downstream/92182;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/912686, chrX-CpG: 27/Downstream/1282740
Nearby gene
P2RY10(-90540) ; GPR174(+118491) ;
Upstream sequence
GAGCTTTGCATGGTGAGGACCCTGCTTCATATTCCTAACCACGCTTGGTGCCAcctacctgcccctgtcttgtccatccctgtgctgaagccactccacc
Downstream sequence
cacaccactagacacctagaaattttactgagatagaagcctccagttattttgtggaatgtattttcaactttctggtacgcaaatgtcttaatgtttt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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