VISDB Viral Integration Site DataBase

VIS ID

TVIS10009041

Fusion event

HBV-PUM1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1765

Orient

+

Integrated sequence

TCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAG| |GTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGT

Chromosome

chr1

Cytoband

p35.2

Reference genome

Start

End

31529482/31056635 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-423-3p ; hsa-mir-151a-3p ; hsa-mir-181a-5p ; hsa-mir-16-5p ; hsa-let-7b-5p ; hsa-mir-296-3p ; hsa-mir-324-3p ; hsa-mir-324-5p ; hsa-mir-186-5p ; hsa-mir-99a-5p ; hsa-mir-568 ; hsa-mir-508-3p ; hsa-mir-219a-5p ; hsa-mir-4445-5p ; hsa-mir-4782-3p ; hsa-mir-6766-3p ; hsa-mir-142-3p ; hsa-mir-1277-5p ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-340-5p ; hsa-mir-6809-5p ; hsa-mir-7112-5p ; hsa-mir-4708-3p ; hsa-mir-651-3p ; hsa-mir-99b-3p ; hsa-mir-99a-3p ; hsa-mir-335-3p ; hsa-mir-4528 ; hsa-mir-4283 ; hsa-mir-760 ; hsa-mir-29a-5p ; hsa-mir-3920 ; hsa-mir-3149 ; hsa-mir-5004-3p ; hsa-mir-3618 ; hsa-mir-4696 ; hsa-mir-571 ; hsa-mir-451b ; hsa-mir-4704-5p ; hsa-mir-548e-5p

Nearest miRNA

hsa-mir-12136/Upstream/317403; hsa-mir-101-1/Downstream/702025;

Nearest TSS

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/147516, chr1-CpG: 60/Downstream/8930

Upstream sequence

acctcccaaagtgttgagattgcaggggtgagccTTCTTTCAGCCTTACAGCTGAAAACCTTCCttttcttttctttttttttttttttttttttttttt

Downstream sequence

tttttttttgagacagggtcccactctgttgcccaggctgaagtgcagtggcatgatctctgttcactgcaacttctgccacccacgctcaagcaatcct