Basic Information
VIS ID
TVIS10009042
Fusion event
HBV-chr14 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2311
Orient
+
Integrated sequence
CACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATG| |CCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATC
Host Sequence
Chromosome
chr14
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
41101498/40632293 (Hg38)
End
41101498/40632293 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-208a/Upstream/3679902; hsa-mir-1185-1/Downstream/7128702;
Nearest TSS
ENST00000550708/Upstream/244735; ENST00000515218/Downstream/322605;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/1199291, chr14-CpG: 47/Downstream/974362
Nearby gene
FBXO33(-1199794) ; LRFN5(+975266) ;
Upstream sequence
CCTTTTATTTTATTGTTTGTAGTAATTTCCTTTTTAACTATCGGTACCTGAGATTTCTCTTTTCTCCATGTTTTCAATATGCTACAGCAGGTCGAACATT
Downstream sequence
TAATTTTGAGCCAAATTGATAAATATGAAATTGTAACTAGTATTATAGCTTACATGACTGTTACTATTTTGAGTACTTTCTCTATTCTTATGGGTCATTC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate