Basic Information
VIS ID
TVIS10009043
Fusion event
HBV-LINC02315 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2888
Orient
-
Integrated sequence
GAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTC| |TTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGG
Host Sequence
Chromosome
chr14
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
41462121/40992916 (Hg38)
End
41462121/40992916 (Hg38)
Orient
+
Location type
Intronic
Target gene
LINC02315
Nearest miRNA
hsa-mir-208a/Upstream/4040525; hsa-mir-1185-1/Downstream/6768079;
Nearest TSS
ENST00000550708/Upstream/38018; ENST00000553926/Downstream/611940;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/1559914, chr14-CpG: 47/Downstream/613739
Nearby gene
FBXO33(-1560417) ; LRFN5(+614643) ;
Upstream sequence
gatcccacagaaatacaatctaccatcagagtatactataaacacctctatgcaaataaactagaaaatctagaagaaatcctaggcaaaacgagcaaag
Downstream sequence
ctggaggcgtcacgctacctgacttcaaactatgctacaaggctacagtaacgaacacagcatggtactggtaccaaaacagatatatagaccaatggag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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