Basic Information
VIS ID
TVIS10009045
Fusion event
HBV-MIR663A integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1815
Orient
-
Integrated sequence
ACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACC| |ATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACC
Host Sequence
Chromosome
chr20
Cytoband
p11.1
Reference genome
GRCh37/hg19
Start
26188865/26208229 (Hg38)
End
26188865/26208229 (Hg38)
Orient
-
Location type
ncRNA_exonic
Target gene
MIR663A
Nearest TSS
ENST00000382410/Upstream/19791; ENST00000400552/Downstream/4080250;
Nearest CpG islands
chr20-CpG: 198/Target, None/Upstream, None/Downstream
Nearest cancer related gene
MIR663A(OG, No orient, 0)
Upstream sequence
CGAGGGCAAGGGCACCTGGGAGCCCGCAGAGGGGCGGCTGAGGGAGAAACCTCAGGCATGGCCGGGCCACCAGGAAAACACGGCCGCGGGATCCCACCGC
Downstream sequence
CACAGACACGAGGGCGGTCCCGCGGCGCCCCGCCTGGGACGCCGGAAGGCCCTCGGCACCCACCAAGACCTGCCTCACGAGCCCCTGGTCCCGCCACCGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate