Basic Information
VIS ID
TVIS10009049
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1825
Orient
-
Integrated sequence
TAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTT| |TTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGA
Host Sequence
Chromosome
chr1
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
178688761/178719626 (Hg38)
End
178688761/178719626 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/41792; hsa-mir-1182/Downstream/1084298;
Nearest TSS
ENST00000473358/Upstream/67920; ENST00000495034/Downstream/5521;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/176405, chr1-CpG: 113/Downstream/5207
Nearby gene
MIR4424(-41792) ; RALGPS2(+5539) ;
Upstream sequence
attcctcatttcctcattatatgctatgtcttcggggaatcacatctggaggcaaatgatgtccgtctgtccctcaattgtgatgttaattttgatcacc
Downstream sequence
tggtgagggttttgtccaatttatccagtgtataattactcatttccttgcaactaataagaagtctatggaaaaatactctaagatcatgcaaatatct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate