VISDB Viral Integration Site DataBase

VIS ID

TVIS10009052

Fusion event

HBV-HIVEP3 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1769

Orient

-

Integrated sequence

GGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCT| |TTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAA

Chromosome

chr1

Cytoband

p34.2

Reference genome

Start

End

42162435/41696764 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-10a-5p ; hsa-mir-26b-5p ; hsa-mir-218-5p ; hsa-mir-149-3p ; hsa-mir-6795-5p ; hsa-mir-6887-5p ; hsa-mir-625-5p ; hsa-mir-486-3p ; hsa-mir-6721-5p ; hsa-mir-92b-5p ; hsa-mir-4763-3p ; hsa-mir-1207-5p ; hsa-mir-4524a-3p ; hsa-mir-211-3p ; hsa-mir-6743-5p ; hsa-mir-4688 ; hsa-mir-4524b-3p ; hsa-mir-6079 ; hsa-mir-3118 ; hsa-mir-134-5p ; hsa-mir-920 ; hsa-mir-6726-5p ; hsa-mir-5591-5p ; hsa-mir-4300 ; hsa-mir-6090 ; hsa-mir-6081 ; hsa-mir-3192-5p ; hsa-mir-4538 ; hsa-mir-4453 ; hsa-mir-100-3p ; hsa-mir-6827-5p ; hsa-mir-4753-3p ; hsa-mir-6873-3p ; hsa-mir-7111-3p ; hsa-mir-130b-5p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-5196-3p ; hsa-mir-3183 ; hsa-mir-3591-3p ; hsa-mir-21-3p ; hsa-mir-6868-3p ; hsa-mir-505-5p ; hsa-mir-4290 ; hsa-mir-3194-5p ; hsa-mir-1237-3p ; hsa-mir-1248 ; hsa-mir-660-3p ; hsa-mir-5193 ; hsa-mir-4687-5p ; hsa-mir-4667-3p ; hsa-mir-6858-3p ; hsa-mir-4494 ; hsa-mir-499b-5p ; hsa-mir-5586-5p ; hsa-mir-665 ; hsa-mir-145-3p ; hsa-mir-2355-5p ; hsa-mir-4794 ; hsa-mir-5580-5p ; hsa-mir-652-5p ; hsa-mir-664a-5p ; hsa-mir-6732-3p

Nearest miRNA

hsa-mir-12136/Upstream/939392; hsa-mir-101-1/Downstream/1474888;

Nearest TSS

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/33803, chr1-CpG: 38/Downstream/221205

Nearest cancer related gene

HIVEP3(TSG, No orient, 0)

Upstream sequence

CACAGAGACAGACGGCCCTGTGCAGCAGCCTGGTTCAATAGCCCAGCTTGAgttaaaaaatagaatgtagagtataatcctaatttaaaaaaaaaaatct

Downstream sequence

gcgtaactgcatagaaaaaaaggtggaagaggaattcactaaatagcccagtcacggatgtggaatagtaggtgaattttttttcctctactttccaaaa