Basic Information
VIS ID
TVIS10009055
Fusion event
HBV-chr14 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2149
Orient
+
Integrated sequence
CCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAG| |ACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTAT
Host Sequence
Chromosome
chr14
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
43135815/42666612 (Hg38)
End
43135815/42666612 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-208a/Upstream/5714221; hsa-mir-1185-1/Downstream/5094383;
Nearest TSS
ENST00000550708/Upstream/254039; ENST00000557465/Downstream/1717933;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/1059486, chr14-CpG: 22/Downstream/2220857
Nearby gene
LRFN5(-762063) ; FSCB(+1837539) ;
Upstream sequence
TTCAGTGATGAGTTAGGAATTATTTCATACTTCAGTTGTGCATTTAATCTTGTTTTAGGGGAATGTTGTATCTTTTTTTTAGTATGTAGAAGTAGTTATA
Downstream sequence
TGCCTCATTATTTATAGTTTAAAGATTCGTATAGAAAGAGGTATGTAAAAATCTAGAGGAAAAAAACTCAGAGCATGGAACAATGACTAGGAAGACACTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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