Basic Information
VIS ID
TVIS10009060
Fusion event
HBV-chr15 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1826
Orient
-
Integrated sequence
AAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTT| |TCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAA
Host Sequence
Chromosome
chr15
Cytoband
q23
Reference genome
GRCh37/hg19
Start
68551878/68259540 (Hg38)
End
68551878/68259540 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10393/Upstream/1762506; hsa-mir-11181/Downstream/542310;
Nearest TSS
ENST00000557528/Upstream/2329; ENST00000570067/Downstream/8753;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/2270, chr15-CpG: 120/Downstream/18096
Nearby gene
CLN6(-29798) ; FEM1B(+18263) ;
Upstream sequence
gactacaggtgcttaccaccatccccagctagttttttttgttgttgttgtatcttttttagaggcagggttttgccattttgcctaggctgatctcaaa
Downstream sequence
ctcctgagttcaagctatccacctgcctcggtctcccaaagtgttgggattacaggcaagagccaccatgctcggccCCCACAAAAAAAAACTTTTAAAC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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