Basic Information
VIS ID
TVIS10009062
Fusion event
HBV-TANGO6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1821
Orient
-
Integrated sequence
TGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAA| |CTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATA
Host Sequence
Chromosome
chr16
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
68970908/68937005 (Hg38)
End
68970908/68937005 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA16B
Target gene
TANGO6
miRNAs that regulate target gene
hsa-mir-320b ; hsa-mir-193b-3p ; hsa-mir-15b-5p ; hsa-mir-222-3p
Nearest miRNA
hsa-mir-1225/Upstream/703506; hsa-mir-11401/Downstream/628803;
Nearest TSS
ENST00000527434/Upstream/27625; ENST00000562000/Downstream/11256;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/93091, chr16-CpG: 203/Downstream/168720
Upstream sequence
AACAAATCACACAAGCTCTTCCACCCTCTTCCTTTCAGAGAAGAGCTTTCATTTCTGGCAAAAGAGCTGAGTGGAGGGAAGGCAAAAGCCCGGAAGGGGG
Downstream sequence
AAGGTAGATACAAGATGAAATTGTTTTCACAGAGTTTCAAATTGAGCAGGATTACAAGTCTTAACTTGTCAGGGCCTGAATCTCTATCTCATTCTCAGAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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