Basic Information
VIS ID
TVIS10009067
Fusion event
HBV-LOC105373456 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1815
Orient
-
Integrated sequence
ACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACC| |ATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACC
Host Sequence
Chromosome
chr2
Cytoband
p24.2
Reference genome
GRCh37/hg19
Start
19102355/18921089 (Hg38)
End
19102355/18921089 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2C
Target gene
LOC105373456
Nearest miRNA
hsa-mir-3125/Upstream/6183645; hsa-mir-10b/Downstream/427340;
Nearest TSS
ENST00000437798/Upstream/136282; ENST00000450628/Downstream/105882;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/336175, chr2-CpG: 71/Downstream/426632
Nearby gene
NT5C1B-RDH14(-331509) ; MIR4757(+445835) ;
Upstream sequence
tcatttcactgaggataatggcctccagttccacccatattgctgcaaaaacatgattacattcttttttatggctaagtagtattccatacctatggtt
Downstream sequence
tttatccaaacattcgttgatggacacttaggctgattccatgactttgctattgtgaatactgctgcaataaccatacaagtgtctttttgatagaatg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate