Basic Information
VIS ID
TVIS10009070
Fusion event
HBV-TMEM161B-AS1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
278
Orient
-
Integrated sequence
TCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTT| |TCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGG
Host Sequence
Chromosome
chr5
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
87651765/88355948 (Hg38)
End
87651765/88355948 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
TMEM161B-AS1
Nearest miRNA
hsa-mir-10397/Upstream/1240994; hsa-mir-103a-1/Downstream/310905;
Nearest TSS
ENST00000502646/Upstream/85442; ENST00000508015/Downstream/36247;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/86884, chr5-CpG: 21/Downstream/246722
Upstream sequence
CTCTAAAAATATTCATTTTTAAAATAGGAAAGGGTATTTCTTCTTTAGTTTTAAGAGTCTTGCAAAGCAAGATACTCGGTACTGAGTCCATGGCATTCTT
Downstream sequence
agtaaaaaatttcttacagttgatggacctacactgacacatgattattacccagagtcctcagtttacattagtattccttctttctattctatattct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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